Intact epidermal cysts, similarly, showcase arborizing telangiectasia; however, ruptured epidermal cysts demonstrate peripheral, linearly branching vessels (45). Dermoscopic features of steatocystoma multiplex, along with milia, as noted in reference (5), include a peripheral brown rim, linear vessels coursing through the lesion, and a uniform yellow background extending throughout. Another crucial observation is that while other previously mentioned cystic lesions are marked by linear vessels, pilonidal cysts are marked by a unique pattern of dotted, glomerular, and hairpin-shaped vessels. Pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma should be part of the differential diagnostic evaluation for pink nodular lesions (3). In our cases and two existing case reports, common dermoscopic signs of pilonidal cyst disease appear to include a pink background, central ulceration, a peripheral distribution of dotted vessels, and the presence of white lines. Dermoscopic characteristics of pilonidal cyst disease, as observed by us, include central yellowish, structureless areas in conjunction with peripheral hairpin and glomerular vessels. Overall, the dermoscopic attributes previously discussed successfully differentiate pilonidal cysts from other skin tumors, and dermoscopy provides substantial support to clinical diagnoses in cases where pilonidal cysts are suspected. To better understand the typical dermoscopic features of this disease and their incidence, further studies are needed.
Editor, I write to you concerning segmental Darier disease (DD), a condition of uncommon occurrence, with approximately 40 instances documented in the English-language medical literature. A potential cause of the disease, according to a hypothesis, is a post-zygotic somatic mutation in the calcium ATPase pump, localized to lesional skin tissue. Blaschko's lines dictate the placement of lesions in segmental DD type 1, which is unilateral; segmental DD type 2, meanwhile, in individuals with generalized DD, is notable for intensely affected focal regions (1). Identifying type 1 segmental DD proves difficult due to the lack of a positive family history, the disease's late appearance in the third or fourth decade of life, and the absence of any associated features indicative of DD. The differential diagnosis of type 1 segmental DD includes acquired papular dermatoses, like lichen planus, psoriasis, lichen striatus, or linear porokeratosis, which are typically arranged in a linear or zosteriform manner (2). In this report, we present two cases of segmental DD, the first being a 43-year-old female who had suffered from pruritic skin alterations for five years, with symptoms worsening during specific seasons. A swirling pattern of light brownish to reddish keratotic small papules was observed on the left abdomen and inframammary area during the examination (Figure 1a). The dermoscopic image (Figure 1b) showed polygonal or roundish, yellowish-brown lesions, surrounded by a band of whitish, featureless tissue. systems biology Dermoscopic brownish polygonal or round areas, as observed, correlate histopathologically with hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes, as evidenced by the biopsy specimen (Figure 1, c). The patient's marked improvement, depicted in Figure 1, subfigure d, was a consequence of the 0.1% tretinoin gel prescription. In the second case, a 62-year-old female presented with a zosteriform rash on her right upper abdomen, consisting of small red-brown papules, eroded papules, and yellowish crusts (Figure 2a). Figure 2b depicts dermoscopic findings: polygonal, roundish, yellowish areas outlined by a structureless field of whitish and reddish tones. Compact orthokeratosis and small parakeratosis foci, coupled with a significant granular layer containing dyskeratotic keratinocytes, and foci of suprabasal acantholysis, provided a conclusive histological diagnosis of DD (Figure 2, d, d). As a consequence of being prescribed topical steroid cream and 0.1% adapalene cream, the patient's condition displayed an improvement. Clinico-histopathologic correlation led to a final diagnosis of type 1 segmental DD in both cases; acantholytic dyskeratotic epidermal nevus, indistinguishable in both clinical and histological presentations from segmental DD, could not be excluded from the diagnosis solely based on the histopathological findings. The diagnosis of segmental DD was substantiated by the late age of symptom onset and the subsequent worsening prompted by external factors like heat, sunlight, and perspiration. While clinical and histopathological observations typically confirm the type 1 segmental DD diagnosis, dermoscopy proves indispensable in the diagnostic process by reducing alternative diagnoses, while paying attention to their characteristic dermoscopic patterns.
Relatively uncommonly, condyloma acuminatum extends to the urethra, most often limited to the distal portion. A substantial body of literature details various approaches to treating urethral condylomas. Extensive and variable therapies include laser treatment, electrosurgery, cryotherapy, and topical cytotoxic agents, exemplified by 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. Intraurethral condylomata are still typically treated with laser therapy as the method of choice. A 25-year-old male patient, exhibiting meatal intraurethral warts, was successfully treated with 5-FU following a series of unsuccessful attempts employing laser treatment, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid.
Erythroderma and generalized scaling serve as hallmarks of a heterogeneous group of skin disorders, ichthyoses. A clear delineation of the relationship between ichthyosis and melanoma has yet to be established. An elderly patient with congenital ichthyosis vulgaris provides a compelling case study for palmar acral melanoma, which we present here. The biopsy sample displayed a superficially spreading melanoma, marked by ulceration. Our current data reveals no instances of acral melanoma in patients who have congenital ichthyosis. Considering the likelihood of melanoma invasion and metastasis, it is essential that patients with ichthyosis vulgaris undertake regular clinical and dermatoscopic evaluations.
This case report concerns a 55-year-old male patient with a diagnosis of penile squamous cell carcinoma (SCC). Immune reconstitution Within the patient's penis, a mass developed and expanded in size incrementally. To eliminate the mass, a partial penectomy was undertaken. The histopathology report indicated a highly differentiated squamous cell carcinoma. The polymerase chain reaction process identified human papillomavirus (HPV) DNA. Upon sequencing, the squamous cell carcinoma was found to contain HPV, of type 58.
A common characteristic of numerous genetic syndromes is the co-occurrence of skin and extracutaneous abnormalities, comprehensively described in medical records. Yet, there could be combinations of symptoms that remain undefined and unclassified. Epigenetics inhibitor The Dermatology Department received a patient with multiple basal cell carcinomas, the source of which was a nevus sebaceous, a case report we present here. The patient's condition encompassed cutaneous malignancies, palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar anomalies, a uterine fibroid, an ovarian cyst, and a highly dysplastic colon polyp. Such a convergence of multiple disorders could signify a genetic basis for the conditions.
Following drug exposure, drug-induced vasculitis develops due to inflammation in small blood vessels, potentially harming the affected tissue. Chemotherapy or the administration of chemoradiotherapy regimens are occasionally linked to rare cases of drug-induced vasculitis, according to medical publications. Our patient received a small cell lung cancer (SCLC) diagnosis, stage IIIA (cT4N1M0). Four weeks after the completion of the second cycle of carboplatin and etoposide (CE) chemotherapy, the patient developed cutaneous vasculitis and a rash localized to the lower limbs. Methylprednisolone therapy, a symptomatic treatment, replaced the CE chemotherapy regimen. With the prescribed corticosteroid treatment, there was a positive change in the local indicators. After chemo-radiotherapy was completed, the patient's treatment continued with four cycles of consolidation chemotherapy which included cisplatin, for a total of six chemotherapy cycles. A clinical examination confirmed a further decline in the cutaneous vasculitis. Elective radiotherapy to the brain was implemented subsequent to the completion of consolidation chemotherapy. The patient's clinical monitoring persisted until the disease's relapse. The platinum-resistant disease prompted subsequent chemotherapy administrations. Following a diagnosis of SCLC, seventeen months later, the patient passed. This is, to the best of our knowledge, the first documented case of lower limb vasculitis that developed in a patient receiving both radiotherapy and CE chemotherapy simultaneously as part of the primary treatment course for SCLC.
Allergic contact dermatitis (ACD), a condition frequently caused by (meth)acrylates, is a traditionally occupational concern for dentists, printers, and fiberglass workers. Documented cases of complications have occurred in both nail technicians and clients who utilize artificial nails. (Meth)acrylates in artificial nails are a significant factor in ACD, raising concerns among both nail technicians and consumers. Following two years of employment as a nail technician, a 34-year-old woman displayed severe hand dermatitis, primarily on her fingertips, in conjunction with frequent occurrences of facial dermatitis. For the past four months, the patient had artificial nails, a choice made due to her nails' susceptibility to splitting, and she consistently applied gel to maintain their integrity. Her asthma manifested in multiple episodes throughout her workday. Patch tests were conducted for baseline series, acrylate series, and the patient's own material.